Which is the correct order of transport of protein in a secretory pathway?

Which is the correct order of transport of protein in a secretory pathway?

(a) Protein synthesized in the cytoplasm-SER lumen-RER lumen-cis Golgi-median Golgi-trans Golgi-vesicles-fusion of vesicles with plasma membrane-exocytosis

(b) Protein synthesized in the cytoplasm-RER lumen-cis Golgi-median Golgi-trans Golgi-vesicles-fusion of vesicles with plasma membrane-exocytosis

(c) Protein synthesized in the cytoplasm- vesicles -SER lumen-RER lumen-cis Golgi-median Golgi-trans Golgi-fusion of vesicles with plasma membrane-exocytosis

(d) Protein synthesized in the cytoplasm- RER lumen-trans Golgi -median Golgi-cis Golgi -vesicles-fusion of vesicles with plasma membrane-exocytosis

This question was posed to me in class test.

I'd like to ask this question from Protein Targeting and Degradation in chapter DNA, RNA and Protein Metabolism of Biochemistry

The KDEL Signal works by Keeping or Retaining ER Lumenal and Membrane Proteins in the ER.

True
False

The Lysosomal Targeting Signal is a Post-Translational Modification

True
False

The nuclear localization signal is a post-translational modification.

True
False

Secretory proteins are synthesized by

a. Ribosomes on the Endoplasmic Reticulum
b. Free Ribosomes
c. Ribosomes on the Nuclear Membrane
d. All of the above

Signal sequences are

a. Short peptide sequences attached to a protein that initiates its degradation by digestive enzymes
b. Short Peptide Sequences that serve as an Address for Transporting Newly Synthesized Proteins to the Correct Location
c. Glycoproteins that serve as an address for transporting newly synthesized proteins to the correct location
d. Short peptide sequences to transport a protein to the nucleus

b. Short Peptide Sequences that serve as an Address for Transporting Newly Synthesized Proteins to the Correct Location

Proteins required in the Cytosol like the Enzymes of Glycolysis are Synthesized on

a. Ribosomes on the Nuclear Membrane
b. Ribosomes on the Endoplasmic Reticulum
c. Free Ribosomes in the Cytosol
d. Smooth Endoplasmic Reticulum

The process of sorting and transporting newly synthesized proteins to their correct destination in a cell is called?

a. Protein Sorting
b. Protein Targeting
c. Protein Trafficking
d. All of these

Proteins containing an NLS are part of the secretion pathway.

True
False

Choose the CORRECT Order of Transport of Proteins in the Secretory Pathway.

a. Protein Synthesized in the Cytoplasm >SER lumen > RER Lumen > cis Golgi >Median Golgi > trans Golgi > Vesicles > Fusion of Vesicles w/ Plasma Membrane > Exoctyosis

b. Protein Synthesized in the Cytoplasm > RER Lumen > cis Golgi >Median Golgi > trans Golgi > Vesicles > Fusion of Vesicles w/ Plasma Membrane > Exoctyosis

c. Protein Synthesized in the Cytoplasm > Vesicles > SER > RER Lumen > cis Golgi > Median Golgi > trans Golgi > Vesicles > Fusion of Vesicles w/ Plasma Membrane > Exoctyosis

d. Protein Synthesized in the Cytoplasm > RER Lumen > trans Golgi > Median Golgi > cis Golgi > Vesicles > Fusion of Vesicles w/ Plasma Membrane > Exoctyosis

b. Protein Synthesized in the Cytoplasm > RER lumen > cis Golgi >Median Golgi > trans Golgi > Vesicles > Fusion of Vesicles w/ Plasma Membrane > Exoctyosis

According to the Signal Hypothesis, the Signal Peptide for a Secretory Protein is?

a. Rich in Hydrophilic Amino Acids @ the Center of the Signal Peptide + is Located @ the C-terminus of the Protein

b. Rich in Hydrophilic Amino Acids @ the Center of the Signal Peptide + is Located @ the N-terminus of the Protein

c. Rich in Hydrophobic Amino Acids @ the Center of the Signal Peptide + is Located @ the C-terminus of the Protein

d. Rich in Hydrophobic Amino Acids @ the Center of the Signal Peptide + is Located @ the N-terminus of the Protein

d. Rich in Hydrophobic Amino Acids @ the Center of the Signal Peptide + is Located @ the N-terminus of the Protein

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What are the steps of the secretory pathway?

The secretory pathway comprises the rough endoplasmic reticulum (rough ER), ER exit sites (ERESs) the ER-to-Golgi intermediate compartment (ERGIC), the Golgi complex and post-Golgi carriers en route to their final destination.

How are secretory proteins transported?

The secretory pathway ensures the transport of proteins from the endoplasmic reticulum (ER) via the Golgi complex to their destination compartment, such as the cell surface, the endosomes or the lysosomes (Boncompain and Weigel, 2018).

What are the steps of protein transport?

From the endoplasmic reticulum, proteins are transported in vesicles to the Golgi apparatus, where they are further processed and sorted for transport to lysosomes, the plasma membrane, or secretion from the cell.

What is the correct order of the exocytosis or secretion pathway?

Steps of exocytosis include vesicle trafficking, tethering, docking, priming, and fusing.

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