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Your immune system does a lot of amazing things. Keeping this system strong helps it fight off infections so you can stay healthy.
Although you’re born with all the cells of your immune system, it gets stronger throughout your life as you expose your body to more germs. This is called acquired immunity.
In this article, we take a closer look at what acquired immunity is, why it’s important, and how you can strengthen it.
Acquired immunity is immunity you develop over your lifetime. It can come from:
- a vaccine
- exposure to an infection or disease
- another person’s antibodies (infection-fighting immune cells)
When pathogens (germs) are introduced into your body from a vaccine or a disease, your body learns to target those germs in the future by making new antibodies.
Antibodies from another person can also help your body fight an infection – but this type of immunity is temporary.
Acquired immunity is different than innate immunity, which you’re born with. Your innate immune system doesn’t fight specific germs.
Instead, it protects against all germs, like bacteria and viruses, by trying to keep them from entering your body. Your innate immune system includes things such as:
- your cough reflex
- stomach acid
- your skin and its enzymes
- mucus
If pathogens get through the barriers in your innate immune system, specific antibodies in the rest of your immune system need to mobilize to fight them off.
Active immunity and passive immunity are the two types of acquired immunity.
Active immunity is the most common type. It develops in response to an infection or vaccination. These methods expose your immune system to a type of germ or pathogen (in vaccinations, just a small amount).
Immune cells called T and B cells recognize there’s an “invader” pathogen and activate the immune system to fight it.
The next time the T and B immune cells encounter that specific germ, they’ll recognize it and immediately activate the rest of your immune system to prevent you from getting sick.
Passive immunity develops after you receive antibodies from someone or somewhere else. This type of immunity is short-lived, because it doesn’t cause your immune system to recognize the pathogen in the future.
There are two main types of passive immunity:
- Maternal antibodies are antibodies that transfer from a mother to child. This usually happens across the placenta or through breast milk, especially in the first few days after birth.
- Immunoglobulin treatments are antibodies that are usually used to treat people at risk for infections, like after a snakebite or a baby born to a mother with hepatitis B. These antibodies are made in a lab, or come from other people or animals.
Both natural and artificial sources of immunity can be active or passive.
- Natural sources aren’t specifically given to you to boost your immunity. Instead, they’re something you acquire by natural means, like an infection or from your mother during birth.
- Artificial sources of immunity are given to you for a specific purpose. They include vaccinations or immunoglobulin treatments.
Your immune system helps keep you healthy by figuring out when something harmful enters your body, and then fighting it so you don’t get sick. The stronger your immune system is, the more likely you are to stay healthy.
A healthy immune system:
- attacks viruses and bacteria that can make you sick
- helps heal wounds
- causes inflammation when it needs to, such as a fever to help get rid of a general infection
- stops long-term inflammation
Acquired immunity makes your immune system stronger. Vaccines, for example, expose your immune system to small amounts of pathogens that won’t make you sick.
Your immune system learns how to recognize those germs, so the next time it encounters them, your immune system will know how to naturally fight them off.
Getting your recommended vaccinations is the best way to boost your acquired immunity.
People need different vaccines depending on their age, where they live, and their job. In general, most adults can boost their immunity with vaccinations against:
Talk to your doctor about what vaccinations you should get.
You can also help boost your immunity by only taking antibiotics for conditions that bacteria — not viruses — cause. For instance, antibiotics won’t help clear up a cold or flu, as a viral infection causes those illnesses.
It’s also important to take the full course of your antibiotics if your doctor prescribes them to help fight off a bacterial infection.
Acquired immunity helps your immune system get stronger. And the stronger your immune system is, the less likely you are to get sick.
When your immune system is exposed to a pathogen, it learns to recognize it. This can make your immune system better equipped to fight off that type of germ the next time you’re exposed to it.
Getting recommended vaccinations is the best way you can help build your acquired immunity and boost your immune system.
The environment contains a wide variety of potentially harmful organisms (pathogens), such as bacteria, viruses, fungi, protozoa and multicellular parasites, which will cause disease if they enter the body and are allowed to multiply. The body protects itself through a various defence mechanisms to physically prevent pathogens from entering the body or to kill them if they do.
The immune system is an extremely important defence mechanism that can identify an invading organism and destroy it. Immunisation prevents disease by enabling the body to more rapidly respond to attack and enhancing the immune response to a particular organism.
Each pathogen has unique distinguishing components, known as antigens, which enable the immune system to differentiate between ‘self’ (the body) and ‘non-self’ (the foreign material). The first time the immune system sees a new antigen, it needs to prepare to destroy it. During this time, the pathogen can multiply and cause disease. However, if the same antigen is seen again, the immune system is poised to confine and destroy the organism rapidly. This is known as adaptive immunity.
Vaccines utilise this adaptive immunity and memory to expose the body to the antigen without causing disease, so that when then live pathogen infects the body, the response is rapid and the pathogen is prevented from causing disease. Depending on the type of infectious organism, the response required to remove it varies. For example, viruses hide within the body’s own cells in different tissues, such as the throat, the liver and the nervous system, and bacteria can multiply rapidly within infected tissues.
Lines of defence
The body prevents infection through a number of non-specific and specific mechanisms working on their own or together. The body’s first lines of defence are external barriers that prevent germs from entering. The largest of all is the skin which acts as a strong, waterproof, physical barrier and very few organisms are able to penetrate undamaged skin. There are other physical barriers and a variety of chemical defences. Examples of these non-specific defences are given below:
- Skin - a strong physical barrier, like a waterproof wall
- Mucus – a sticky trap secreted by all the surfaces inside the body that are directly linked to the outside, also contains antibodies and enzymes
- Cilia – microscopic hairs in the airways that move to pass debris and mucus up away from the lungs
- Lysozyme – a chemical (enzyme) present in tears and mucus that damages bacteria
- Phagocytes – various cells that scavenge and engulf debris and invading organisms, which form part of the surveillance system to alert the immune system of attack
- Commensal bacteria - bacteria on skin and gut that compete with potentially harmful bacteria for space and nutrients
- Acid - in stomach and urine, make it hard for any germs to survive
- Fever – elevated body temperature making conditions unfavourable for pathogens to survive
The immune response
An immune response is triggered when the immune system is alerted that something foreign has entered the body. Triggers include the release of chemicals by damaged cells and inflammation, and changes in blood supply to an area of damage which attract white blood cells.
White blood cells destroy the infection or convey chemical messages to other parts of the immune system. As blood and tissue fluids circulate around the body, various components of the immune system are continually surveying for potential sources of attack or abnormal cells.
Antigens and antibodies
Antigens are usually either proteins or polysaccharides (long chains of sugar molecules that make up the cell wall of certain bacteria). An antigen is a molecule that stimulates an immune response and to which antibodies bind – in fact, the name is derived from “antibody generators.” Any given organism contains several different antigens. Viruses can contain as few as three antigens to more than 100 as for herpes and pox viruses; whereas protozoa, fungi and bacteria are larger, more complex organisms and contain hundreds to thousands of antigens.
An immune response initially involves the production of antibodies that can bind to a particular antigen and the activation of antigen-specific white blood cells.
Antibodies (immunoglobulins; Ig) are protein molecules that bind specifically to a particular part of an antigen, so called antigenic site or epitope. They are found in the blood and tissue fluids, including mucus secretions, saliva and breast milk. There are five classes of antibody – IgG, IgA, IgM, IgD and IgE, which have a range of functions. They can act as ‘flags’ to direct the immune system to foreign material for destruction and form part of the innate / humoral immune response. Normally, low levels of antibodies circulate in the body tissue fluids. However, when an immune response is activated greater quantities are produced to specifically target the foreign material.
Vaccination increases the levels of circulating antibodies against a certain antigen. Antibodies are produced by a type of white blood cell (lymphocyte) called B cells. Each B cell can only produce antibodies against one specific epitope. When activated, a B cell will multiply to produce more clones able secrete that particular antibody. The class of antibody produced is determined by other cells in the immune system, this is known as cell-mediated immunity.
Primary response
Upon exposure to a pathogen, the body will attempt to isolate and destroy it. Chemicals released by inflammation increase blood flow and attract white blood cells to the area of infection. Specialist cells, known as phagocytes, engulf the target and dismantle it. These phagocytes then travel to the nearest lymph nodes where they ‘present’ the antigens to other cells of the immune system to induce a larger, more specific response. This response leads to the production of antigen-specific antibodies.
Circulating antibodies then find the organism and bind to its surface antigens. In this way it is labelled as the target. This specific response is also called the adaptive or cell-mediated immune response, since the immune system adapts to suit the type of invader.
When the body is first exposed to an antigen, several days pass before this adaptive response becomes active. Upon first exposure to a pathogen, immune activity increases, then levels off and falls. Since the first, or primary, immune response is slow it cannot prevent disease, although it may help in recovery.
Once antigen-specific T and B cells (lymphocytes) are activated, their numbers expand and following an infection some memory cells remain resulting in memory for the specific antigens. This memory can take a few months to fully develop.
Secondary response
During subsequent exposures to the same pathogen, the immune system is able to respond rapidly and activity reaches higher levels.
The secondary immune responses can usually prevent disease, because the pathogen is detected, attacked and destroyed before symptoms appear. In general, adults respond more rapidly to infection than children. They are able to prevent disease or reduce the severity of the disease by mounting a rapid and strong immune response to antigens they have previously experienced. In contrast, children have not experienced as many antigens and are more likely to get sick.
Memory of the infection is reinforced and long lived antibodies remain in circulation. Some infections, such as chickenpox, induce a life-long memory of infection. Other infections, such as influenza, vary from season to season to such an extent that even an adult is unable to adapt.
Vaccination
Vaccination utilises this secondary response by exposing the body to the antigens of a particular pathogen and activates the immune system without causing disease.
The initial response to a vaccine is similar to that of the primary response upon first exposure to a pathogen, slow and limited. Subsequent doses of the vaccine act to boost this response resulting in the production of long-lived antibodies and memory cells, as it would naturally following subsequent infections.
The aim of vaccines is to prime the body, so that when an individual is exposed to the disease-causing organism, their immune system is able to respond rapidly and at a high activity level, thereby destroying the pathogen before it causes disease and reduces the risk of spread to other people.
Vaccines vary in how they stimulate the immune system. Some provide a broader response than others. Vaccines influence the immune response through the nature of the antigens they contain, including number and characteristics of the antigens, or through the route of administration, such as orally, intramuscular or subcutaneous injection. The use of adjuvants in vaccines can help to determine the type, duration and intensity of the primary response and the characteristics of resulting antigen-specific memory.
For most vaccines, more than one dose may be required to provide sustained, long-lasting protection – to be fully immunised.
Types of immunisation
Active immunisation – body generates its own response to protect against infection through specialised cells and antibodies, as stimulated by vaccines. Full protection takes time to develop but is long lasting.
Passive immunisation – ready-made antibodies are passed directly to the person being immunised. This allows for immediate protection, but passive immunisation may only last a few weeks or months. Antibodies are passed from mothers to infants across the placenta and in breast milk, to protect the infants for a short time after birth. Antibodies (immunoglobulins) are also purified from blood or in laboratories; these can be directly injected to provide rapid but short lived protection or treatment for certain diseases, such as rabies, diphtheria and tetanus.