OVERVIEWIntroductionMove Free is a proprietary line of multi-ingredient dietary supplements (MIDS) marketed as aids for joint health and “to help ease joint discomfort, maintain strength and flexibility and help support and nourish cartilage”. The major ingredients in the products include glucosamine, chondroitin, hyaluronic acid and methylsufonylmethane (MSM). There have been several reports of clinically apparent liver injury in patients taking Move Free products; however, the specific ingredient(s) in the various products that might cause liver injury has not been identified and these ingredients may no longer be included in currently available products. Show
BackgroundMove Free is a proprietary product name for an array of multi-ingredient herbal and dietary supplements (MIDS) meant to ease joint discomfort. The Move Free brand is currently produced by Reckitt Benckiser Group plc (Slough, England) which purchased its previous distributor, Schiff Nutrition International (Salt Lake City, UT), in 2012. The constituents of the various Move Free products vary, but are largely glucosamine, chondroitin and hyaluronic acid with various combinations of vitamins (vitamin D3), minerals (boron) and selected nutritional supplements such as krill oil and astaxanthin (a keto-carotenoid anti-oxidant). The ingredients and their concentrations in some of the products have been modified over time. Previous Move Free products have included mixtures of herbal agents including Chinese skullcap (Scutellaria baicalensis) and black catechu (Acacia catechu). Presently, however, Move Free products do not list any herbal constituents although several mention “Uniflex (FruiteX-B Calcium Fructoborate)”. The common Move Free products that are currently marketed are given in the Table below with a listing of their ingredients as provided in the product labels. Because the products are considered dietary supplements, they are not subject to the usual efficacy and safety evaluation given to medications. However, all nutritional supplements are subject to rules regarding purity and good manufacturing practices. Dietary supplements are not recommended for specific medical conditions, but can be advertised as being supportive of general health or a specific tissue or organ health. These multi-ingredient products appear to be generally safe and well tolerated, but prospective studies of their efficacy, tolerance and safety have not been published. Selected Move Free Products (February 2016)
HepatotoxicityThe initial reports of liver injury attributed to Move Free were published in 2010, with subsequent reports in 2012 and 2013, all from the United States. These publications described an acute hepatocellular injury arising within 1 to 3 weeks of starting a Move Free product that contained glucosamine, chondroitin and a proprietary herbal mixture of Chinese skullcap (Scutellaria baicalensis) and black catechu (Acacia catechu). The injury was moderate in severity and resolved within 1 to 2 months of stopping the supplement. Immunoallergic and autoimmune features were not present, and the injury resolved without residual in all cases. One patient restarted the product after at least partial recovery and redeveloped a similar pattern of liver injury. While further cases have not been described, prospective studies of drug induced liver injury from the United States mentioned 3 cases of acute liver injury linked to Move Free products, all from 2012-2013. At present, Move Free products do not list a proprietary herbal component but do mention a proprietary mineral complex with a similar name: “Uniflex”. Likelihood score: C (probable rare cause of clinically apparent liver injury). Mechanism of InjuryThe liver injury attributed to Move Free products has been reported to be due to Chinese skullcap, but the mechanism by which this herb might cause liver injury is unexplained. Indeed, Chinese skullcap has hepatoprotective activity in animal models of liver disease. Contamination or misidentification of the herbal components is always a possibility in explaining the appearance of liver injury. Outcome and ManagementThe liver injury that has been attributed to Move Free products has usually been mild-to-moderate in severity and self-limited in course, resolving in 1 to 2 months of stopping the preparations. Move Free has not been linked to instances of acute liver failure, chronic hepatitis or vanishing bile duct syndrome. In patients presenting with acute, unexplained liver injury, all HDS products should be discontinued and the case reported to federal registries. It is also helpful to carefully define what products were being taken and at what doses and for how long. Retrieval of the actual product or products can also be helpful as progress is being made in the identification of ingredients by advanced chemical and biochemical methods. Drug Class: Herbal and Dietary Supplements, Nutritional Supplements, Multi-Ingredient CASE REPORTCase 1. Repeated episodes of acute hepatitis after use of Move Free.(1)A 78 year old woman osteoarthritis developed jaundice within 3 weeks of starting “Move Free Advanced”, a proprietary multi-ingredient nutritional supplement advertised to be helpful for joint discomfort. She had no history of liver disease, but had a previous cholecystectomy. She denied alcohol abuse and risk factors for viral hepatitis. She was taking no other medications except for multivitamins. On presentation, serum bilirubin was 7.2 mg/dL, ALT 1626 U/L, AST 1053 U/L, alkaline phosphatase 354 U/L and GGT 599 U/L. Tests for hepatitis A, B and C were negative. She was hospitalized and the Move Free product was stopped. She began to improve without specific therapy and was discharged after a few days (Table). Because her joint symptoms worsened, she restarted the Move Free product and redeveloped jaundice within two weeks. Her laboratory tests were again abnormal in a pattern similar to the initial episode. A liver biopsy showed acute hepatocellular injury with many eosinophils suggestive of drug induced liver injury. Tests for autoantibodies were negative and a CT scan of the abdomen showed no evidence of biliary obstruction or hepatic masses. At this point, the nutritional supplement was suspected to be the cause and was found to be Move Free Advanced and have glucosamine, chondroitin and two herbal ingredients, Chinese skullcap and black catechu listed together as “Uniflex Proprietary Extract: 200 mg”. She was told to avoid its further use and in follow up her symptoms resolved and liver tests improved. Key Points
Laboratory Values
CHEMICAL FORMULAS AND STRUCTURES
ANNOTATED BIBLIOGRAPHYReferences updated: 26 February 2020 Abbreviations: HDS, herbal and dietary supplements.
Is move free an anti inflammatory?Move Free Ingredients
Glucosamine has been shown to be effective for joint pain specifically [1] but, researchers haven't seen any improvements to joint health or inflammation.
What's a good supplement for joint pain?Several nutritional supplements have shown promise for relieving pain, stiffness and other arthritis symptoms. Glucosamine and chondroitin, omega-3 fatty acids, SAM-e and curcumin are just some of the natural products researchers have studied for osteoarthritis (OA) and rheumatoid arthritis (RA).
How long does it take joint supplements to work?The effects of glucosamine and chondroitin may not be noticeable for at least six to eight weeks, and their benefits become apparent in about four to six months. If no benefit is seen after six months, the supplement should be discontinued.
What vitamin is good for joint support?Vitamin D
Vitamin D also assists in the body's absorption of calcium. By taking this vitamin, one can help strengthen the bones and joints. It is possible to find vitamins that contain both calcium and vitamin D.
|