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SusceptibleImmune due to Successful VaccinationImmune due to Resolved infectionAcute HBVPrior HBV and isolated HBcAb+*Test is only needed if patient is HBsAg positive or there is suspicion of occult HBV.HBV surface antigen (HBsAg)NegNegNegPosNegHBV surface antibody (HBsAb)NegPosPosNegNegHBV core antibody IgG (HBcAb IgG)negNegPosPosPosHBV core antibody IgM (HBcAb IgM)NegNegNegPosNegHBeAg*Not applicableNot applicableNot applicableNegNegHBeAb*Not applicableNot applicableNot applicableNegPosHBV DNA*Not applicableNot applicableNot applicableNeg or PosNegALT*Not applicableNot applicableNot applicableElevatedTypically Normal Occult HBV, with loss of HBsAgChronic Inactive HBVChronic HBV, e-Ag positiveChronic HBV, e-Ag negativeReactivation of Chronic HBV*Test is only needed if patient is HBsAg positive or there is suspicion of occult HBV.HBsAgNegPosPosPosPosHBV surface antibody (HBsAb)NegNegNegNegNegHBV core antibody IgG (HBcAb IgG)PosPosPosPosPosHBV core antibody IgM (HBcAb IgM)NegNegNegNegNegHBeAg*NegNegPosNegPos or NegHBeAb*PosPosNegPosPos or NegHBV DNA*PosNeg or Low LevelPosPosPosALT*Variable (Normal-Elevated)NormalVariable (Normal-Elevated)Variable (Normal-Elevated)Elevated The hepatitis B blood tests are collectively known as the serologic panel. This set of tests can accurately diagnose current and past hepatitis B infection. Since there are a number of markers and at least six interpretations of the various results, determining their meaning can be challenging. To help clarify, below are the six interpretations organized in a table from these hepatitis B markers. Don Bayley / Getty ImagesTests in the Hepatitis B Serologic Panel
If you're acutely or chronically infected with hepatitis B, then it's possible for you to spread the virus to others. Follow standard prevention and make sure to protect yourself and others during sexual contact. Understanding the Hepatitis B e-Antigen (HBeAg) 6 Interpretations of the Serologic Panel1. If Your Tests Are:
You're probably susceptible to hepatitis B. If you are eligible for the hepatitis B vaccine, you could get vaccinated to reduce your risk of infection in the future. 2. If Your Tests Are:
You're probably immune due to natural infection. You don't have the viral antigen circulating, but you are showing both antibodies. The core antibody is the one that indicates this was due to infection rather than vaccination. Often people are surprised to learn they had an infection in the past, as many cases have only minor symptoms. 3. If Your Tests Are:
You're probably immune due to hepatitis B vaccination. Often this is the result seen on follow-up after immunization and it is a good outcome. If you weren't vaccinated, that is something your healthcare provider will explore further. 4. If Your Tests Are:
You're probably acutely infected. The presence of IgM anti-HBc, along with HBsAg, shows that there is virus circulating in your body and you are producing an early reaction to it. This wouldn't be the case with a chronic infection or an infection further in the past that you recovered from. 5. If Your Tests Are:
You're probably chronically infected. You are continuing to make core antibody and you have virus circulating, but your early IgM antibody has faded away. In this case, your healthcare provider will most likely obtain liver function tests and viral DNA levels to determine eligibility for treatment. 6. If Your Tests Are:
With this result, it could be several things, the most common of which is that you had a hepatitis B infection that has resolved or is resolving. You probably aren't in the acute infection stage. You might have a false-positive test for the core antibody. You aren't immune to hepatitis B, so you need to take care of exposure risk and you should discuss whether vaccination is advised. You may also have a low-level chronic Hepatitis B infection. How do you read hepatitis B blood test results?Normal hepatitis B core antibody results are negative. A positive hepatitis B core antibody test may mean you have a current or past hepatitis B infection. A positive hepatitis B surface antibody test means you are protected against the hepatitis B virus.
What is the normal range of hepatitis B?Normal range for this assay is Not Detected. The quantitative range of this assay is 1.00-9.00 log IU/mL (10-1,000,000,000 IU/mL). An interpretation of "Not Detected" does not rule out the presence of inhibitors in the patient specimen or HBV DNA concentration below the level of detection of the test.
What are the important hepatitis B markers?Serological markers for HBV infection consist of HBsAg, anti-HBs, HBeAg, anti-HBe, and anti-HBc IgM and IgG.
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