What drugs are used in sports?

The use of prohibited substances in sport is a world-wide problem.

The pressures and expectations to win, or to perform at the elite level, can lead some athletes to use prohibited substances and/or prohibited methods.

Prohibited substances and methods are used in sport to enhance performance, promote recovery, to improve body appearance, and to create an unfair advantage over other competitors. However, the AMA also recognises that the use of performance- and image-enhancing drugs (PEIDs) is not isolated to elite athletes, but also seen in developing and sub-elite athletes, as well as school students and body builders.

In Australia, ASADA (Australian Sports Anti-Doping Authority) oversees a comprehensive anti-doping program, including education, deterrence, detection, and enforcement. ASADA also collaborates with WADA (World Anti-Doping Agency), which is responsible for producing the annually updated Prohibited List, to ensure consistent anti-doping practices and policies. The AMA supports compliance with world anti-doping policies to ensure Australian sport is ‘clean’, and the health and integrity of our athletes and sporting codes are maintained.

Recreational drugs commonly used in Australia are also prohibited under anti-doping codes. These include stimulants (amphetamines, methamphetamine, cocaine, and ecstasy like drugs including MDMA, MDA and MDEA), narcotic analgesics, and opiates (heroin, morphine, pethidine).

The AMA Position Statement on Harmful substance use, dependence, and behavioural addiction (Addiction) – 2017 addresses substance dependencies and behavioural addictions that can be detrimental to individuals and the community. The AMA recognises substance use in the general community as a serious health condition, and argues that those who are affected should be treated like other patients with serious illness, and be offered the best available treatments and supports to aid recovery. This may include innovative policy models and trials, in a controlled manner, funded and evaluated appropriately, that might reduce harms and improve outcomes for users and society at large.

There are also distinct health risks involved in using many of the prohibited substance and methods in sport, which is one of the reasons they are banned by sports governing bodies.

Some prohibited substances are contained in commonly used prescription medications (e.g. insulin), or in over the counter medication (e.g. pseudoephedrine) due to their performance enhancing effects.

Some dietary supplements also contain prohibited substances. These have extra risks because the Therapeutic Goods Administration (TGA) regulations are less stringent, and supplements may contain substances that are not written on their labels. This results in a potential health risk, as well as an anti-doping risk, as athletes cannot always be sure that the supplement they are taking is “safe”. ASADA recommends athletes perform a series of checks, which includes having independent batch testing of any supplements before they are used.[1]

Any sportsperson taking medications, supplements, or alternative medicines of any kind should be aware that some of these preparations may contain prohibited substances, or be a prohibited method, which could result in positive anti-doping tests and, ultimately, sanctions.

Medical practitioners have an important role in not only helping to deter any patient from using drugs – both legal and prohibited by anti-doping agencies – for non-medical purposes, but also ensuring that they do not prescribe prohibited drugs to athletes who may be drug tested. The doctor's role should also extend to advice to participants at all levels on illicit drug use.

Australia has very high rates of sporting participation and attendance, and an enviable record of sporting achievement. Every effort must be made to ensure Australian athletes and sport are ‘clean’.

 

The AMA Position:

  1. Using performance-enhancing substances and methods tarnishes the health, reputations, and records of athletes and sporting teams, and every appropriate effort must be made to eliminate the use of banned substances and methods.
  2. The systematic detection and enforcement of anti-doping policies must be maintained at the elite level, with education an important part of the process, and must extend to lower level and community athletes.
  3. Medical practitioners have a very important role in helping prevent the use of performance-enhancing and banned substances and methods.
  4. Medical practitioners should advise all patients who participate in competitive sport to check all medications they take against the WADA Prohibited List – the international standard identifying substances and methods prohibited in sport, prepared and updated by the World Anti-Doping Agency (WADA).) The checking tool is: www.globaldro.com.
  5. Medical practitioners should also check the medications they prescribe (Globaldro and/or MIMS) to elite athletes to avoid prescribing medications that are prohibited.
  6. Medical practitioners should be aware that there is a process in place to allow them to prescribe WADA Prohibited medications to athletes if there are no alternatives. This is called a Therapeutic Use Exemption (TUE), and is administered by ASDMAC (Australian Sports Drug Medical Advisory Committee), an independent panel of medical practitioners[2] who assess and decide on these applications.
  7. Medical practitioners must be aware that conflicts of interest may arise between the health of individual athletes and those of teams, as well as possible conflicts between the privacy of athletes and the sharing of individual health records, diagnosis, and treatment. However, medical practitioners have a duty of care to individual athletes, and should never assist any athlete to engage in doping practices or any other unethical performance-enhancing methods.
  8. Medical practitioners should be informed about the appropriate medical prescribing rules for steroids, human growth hormones, stimulants and other substances that may be used inappropriately by athletes.
  9. The prescription or administration of medically unnecessary substances, or the employment of medically inappropriate practices, including those intended to enhance performance in sport or body image, is unethical and cannot be condoned.
  10. Athletes, coaches, administrators and sports physicians are bound to make correct ethical and legal choices, and adhere to the rules regarding the use of prohibited substances and methods. The WADA Code has provisions for sanctions against medical professionals who knowingly prescribe or provide performance enhancing drugs to athletes.[3]
  11. On-going research is needed into the use, availability, and effects of drugs in sport.
  12. The Federal Government, along with agencies such as ASADA and the TGA, should regularly distribute relevant information and updated information about drugs in sport to all Australian medical practitioners, pharmacists, legislators, sporting organisations, educators and sporting organisations.

[1] For further information: see Australasian College of Sports Physicians Statement http://www.acsep.org.au/content/Document/ACSEP%20Supplement%20Position%20Statement%20final%20171117.pdf and ASADA supplement statement https://www.asada.gov.au/substances/supplements.

[2] See:www.asdmac.gov.au.

[3] See https://www.asada.gov.au/rules-and-violations/anti-doping-rule-violations

1. Baron DA, Martin DM, Abol Magd S. Doping in sports and its spread to at-risk populations: an international review. World Psychiatry. 2007;6:118–123. [PMC free article] [PubMed] [Google Scholar]

2. Catlin DH, Murray TH. Performance-enhancing drugs, fair competition, and Olympic sport. JAMA. 1996;276:231–237. [PubMed] [Google Scholar]

3. Fernandez MM, Hosey RG. Performance-enhancing drugs snare nonathletes, too. J Fam Pract. 2009;58:16–23. [PubMed] [Google Scholar]

4. Metzl JD, Small E, Levine SR, Gershel JC. Creatine use among young athletes. Pediatrics. 2001;108:421–425. [PubMed] [Google Scholar]

5. Uvacsek M, Nepusz T, Naughton DP, Mazanov J, Ranky MZ, Petroczi A. Self-admitted behavior and perceived use of performance-enhancing vs psychoactive drugs among competitive athletes. Scand J Med Sci Sports. 2011;21:224–234. [PubMed] [Google Scholar]

6. National Institute on Drug Abuse, US Department of Health and Human Services Monitoring the future national survey on drug use, 1975–2003, volume II. College students and adults ages 19–25. [Accessed June 12, 2014]. Available from: http://www.monitoringthefuture.org/pubs/monographs/vol2_2003.pdf.

7. Green GA, Uryasz FD, Petr TA, et al. NCAA study of substance abuse habits of college student-athletes. Clin J Sports Med. 2001;11:51–56. [PubMed] [Google Scholar]

8. Kersey RD, Elliot DL, Goldberg L, et al. National Athletic Trainers’ Association position statement: anabolic-androgenic steroids. J Athl Train. 2012;47:567–588. [PMC free article] [PubMed] [Google Scholar]

9. Cottler LB, Abdallah AB, Cummings SM, Barr J, Banks R, Forchheimer R. Injury, pain, and prescription opioid use among former National Football League (NFL) players. Drug Alcohol Depend. 2011;116:188–194. [PMC free article] [PubMed] [Google Scholar]

10. McDuff DR, Baron D. Substance use in athletics: a sports psychiatry perspective. Clin Sports Med. 2005;24:885–897. [PubMed] [Google Scholar]

11. Wanjek B, Rosendahl J, Strauss B, Gabriel HH. Doping, drugs and drug abuse among adolescents in the State of Thuringia (Germany): prevalence, knowledge and attitudes. Int J Sports Med. 2007;28:346–353. [PubMed] [Google Scholar]

12. Botre F, Pavan A. Enhancement drugs and the athlete. Phys Med Rehabil Clin N Am. 2009;20:133–148. [PubMed] [Google Scholar]

13. Morse ED. Substance use in athletes. In: Baron DA, Reardon CL, Baron SH, editors. Clinical Sports Psychiatry: An International Perspective. Oxford, UK: Wiley; 2013. [Google Scholar]

14. Reardon CL, Factor RM. A systematic review of diagnosis and medical treatment of mental illness in athletes. Sports Med. 2010;40:961–980. [PubMed] [Google Scholar]

15. Riggs P, Levin F, Green AI, et al. Comorbid psychiatric and substance abuse disorders: recent treatment research. Subst Abuse. 2008;29:51–63. [PubMed] [Google Scholar]

16. Baron DA, Reardon CL, Baron SH. Doping in sport. In: Baron DA, Reardon CL, Baron SH, editors. Clinical Sports Psychiatry: An International Perspective. Oxford, UK: Wiley; 2013. [Google Scholar]

17. Yesalis CE. History of doping in sport. In: Bahrke MS, Yesalis CE, editors. Performance Enhancing Substances in Sport and Exercise. Champaign, IL, USA: Human Kinetics; 2002. [Google Scholar]

18. Landry GL, Kokotailo PK. Drug screening in athletic settings. Curr Problems Pediatr. 2004;24:344–359. [PubMed] [Google Scholar]

19. Franke WW, Berendonk B. Hormonal doping and androgenization of athletes: a secret program of the German Democratic Republic. Clin Chem. 1997;43:1262–1279. [PubMed] [Google Scholar]

20. McGann B, McGann C. The Story of the Tour de France. Indianapolis, IN, USA: Dog Ear Publishing; 2006. [Google Scholar]

21. Teale P, Scarth J, Judson S. Impact of the emergence of designer drugs upon sports doping testing. Bioanalysis. 2012;4:71–88. [PubMed] [Google Scholar]

22. International Association of Athletics Federations IAAF commitment to healthy and drug free athletic. 2013. [Accessed August 29, 2013]. Available from: http://www.iaaf.org/about-iaaf/medical-anti-doping.

23. Federation Internationale de Football Association A brief history of doping. 2013. [Accessed August 29, 2013]. Available from: http://www.fifa.com/aboutfifa/footballdevelopment/medical/news/newsid=514062/index.html.

24. International Olympic Committee Factsheet: the fight against doping and promotion of athletes’ health. 2013. [Accessed August 29, 2013]. Available from: http://www.olympic.org/Documents/Reference_documents_Factsheets/Fight_against_doping.pdf.

25. World Anti-Doping Agency A brief history of anti-doping. 2010. [Accessed August 29, 2013]. Available from: http://www.wada-ama.org/en/about-wada/history/

26. Voet W. Breaking the Chain. London, UK: Random House; 1999. [Google Scholar]

27. Bhasin S, Storer TW, Berman N, et al. The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men. N Engl J Med. 1996;335:1–7. [PubMed] [Google Scholar]

28. Bhasin S, Woodhouse L, Casaburi R, et al. Testosterone dose-response relationships in healthy young men. Am J Physiol Endocrinol Metab. 2001;281:E1172–E1181. [PubMed] [Google Scholar]

29. Storer TW, Magliano L, Woodhouse L, et al. Testosterone dose-dependently increases maximal voluntary strength and leg power, but does not affect fatigability or specific tension. J Clin Endocrinol Metab. 2003;88:1478–1485. [PubMed] [Google Scholar]

30. Wallace MB, Lim J, Cutler A, Bucci L. Effects of dehydroepiandrosterone vs androstenedione supplementation in men. Med Sci Sports Exerc. 1999;31:1788–1792. [PubMed] [Google Scholar]

31. Morales AJ, Haubrich RH, Hwang JY, Asakura H, Yen SS. The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women. Clin Endocrinol. 1998;49:421–432. [PubMed] [Google Scholar]

32. Kohler M, Thomas A, Geyer H, Petrou M, Schanzer W, Thevis M. Confiscated black market products and nutritional supplements with non-approved ingredients analyzed in the Cologne Doping Control Laboratory 2009. Drug Test Anal. 2010;2:533–537. [PubMed] [Google Scholar]

33. Handelsman DJ. Clinical review: the rationale for banning human chorionic gonadotropin and estrogen blockers in sport. J Clin Endocrinol Metab. 2006;91:1646–1653. [PubMed] [Google Scholar]

34. Handelsman DJ. Indirect androgen doping by oestrogen blockage in sports. Br J Pharmacol. 2008;154:598–605. [PMC free article] [PubMed] [Google Scholar]

35. Basaria S. Androgen abuse in athletes: detection and consequences. J Clin Endocrinol Metab. 2010;95:1533–1543. [PubMed] [Google Scholar]

36. Meinhardt U, Nelson AE, Hansen JL, et al. The effects of growth hormone on body composition and physical performance in recreational athletes: a randomized trial. Ann Intern Med. 2010;152:568–577. [PubMed] [Google Scholar]

37. Holt RI, Sonksen PH. Growth hormone, IGF-I and insulin and their abuse in sport. Br J Pharmacol. 2008;154:542–556. [PMC free article] [PubMed] [Google Scholar]

38. Eichner ER. Stimulants in sports. Curr Sports Med Rep. 2008;7:244–245. [PubMed] [Google Scholar]

39. Higgins P, Tuttle TD, Higgins CL. Energy beverages: content and safety. Mayo Clin Proc. 2010;85:1033–1041. [PMC free article] [PubMed] [Google Scholar]

40. National College Athletic Association NCAA guidelines to document ADHD treatment with banned stimulant medications. Addendum to the Jan 2009 guideline. 2010. [Accessed June 12, 2014]. Available from: http://www.lagrange.edu/resources/pdf/athletics/athletictraining/FAQ.pdf.

41. Shaikin B. Los Angeles Times. Baseball’s 2008 drug test results released in report. Jan 10, 2009. [Accessed September 17, 2010]. Available from: http://articles.latimes.com/2009/jan/10/sports/sp-newswire10.

42. Judkins C, Prock P. Supplements and inadvertent doping – how big is the risk to athletes. Med Sports Sci. 2012;59:143–152. [PubMed] [Google Scholar]

43. Kendall KL, Smith AE, Graef JL, et al. Effects of four weeks of high-intensity interval training and creatine supplementation on critical power and anaerobic working capacity in college-aged men. J Strength Cond Res. 2009;23:1663–1669. [PubMed] [Google Scholar]

44. Branch JD. Effect of creatine supplementation on body composition and performance: a meta-analysis. Int J Sport Nutr Exerc Metab. 2003;13:198–226. [PubMed] [Google Scholar]

45. Elliott S. Erythropoiesis-stimulating agents and other methods to enhance oxygen transport. Br J Pharmacol. 2008;154:529–541. [PMC free article] [PubMed] [Google Scholar]

46. Bailey JA, Averbuch RN, Gold MS. Cosmetic psychiatry: from Viagra to MPH. Directions in Psychiatry. 2009;29:1–13. [Google Scholar]

47. Kindermann W. Do inhaled beta(2)-agonists have an ergogenic potential in non-asthmatic competitive athletes? Sports Med. 2007;37:95–102. [PubMed] [Google Scholar]

48. Davis E, Loiacono R, Summers RJ. The rush to adrenaline: drugs in sport acting on the beta-adrenergic system. Br J Pharmacol. 2008;154:584–597. [PMC free article] [PubMed] [Google Scholar]

49. Bougault V, Boulet LP. Is there a potential link between indoor chlorinated pool environment and airway remodeling/inflammation in swimmers? Expert Rev Respir Med. 2012;6:469–471. [PubMed] [Google Scholar]

50. World Anti-Doping Agency The World Anti-Doping Code: The 2013 Prohibited List International Standard. 2013. [Accessed August 23, 2013]. Available from: http://www.wada-ama.org/Documents/World_Anti-Doping_Program/WADP-Prohibited-list/2013/WADA-Prohibited-List-2013-EN.pdf.

51. Petroczi A, Naughton DP. Potentially fatal new trend in performance enhancement: a cautionary note on nitrate. J Int Soc Sports Nutr. 2010;7:25. [PMC free article] [PubMed] [Google Scholar]

52. Watson P, Hasegawa H, Roelands B, Piacentini MF, Looverie R, Meeusen R. Acute dopamine/noradrenaline reuptake inhibition enhances human exercise performance in warm, but not temperate conditions. J Physiol. 2005;565(Pt 3):873–883. [PMC free article] [PubMed] [Google Scholar]

53. Schmitt L, Millet G, Robach P, et al. Influence of “living high-training low” on aerobic performance and economy of work in elite athletes. Eur J Appl Physiol. 2006;97:627–636. [PubMed] [Google Scholar]

54. Vardy J, Judge K. Can knowledge protect against acute mountain sickness? J Public Health. 2005;27:366–370. [PubMed] [Google Scholar]

55. Suedekum NA, Dieff R. Iron and the athlete. Curr Sports Med Rep. 2005;4:199–202. [PubMed] [Google Scholar]

56. Maughan RJ, Shirreffs SM. Nutrition for sports performance: issues and opportunities. Proc Nutr Soc. 2012;71:112–119. [PubMed] [Google Scholar]

57. Koshy KM, Griswold E, Schneeberger EE. Interstitial nephritis in a patient taking creatine. N Engl J Med. 1999;340:814–815. [PubMed] [Google Scholar]

58. Edmunds JW, Jayapalan S, DiMarco NM, Saboorian MH, Aukema HM. Creatine supplementation increases renal disease progression in Han:SPRD-cy rats. Am J Kidney Dis. 2001;37:73–78. [PubMed] [Google Scholar]

59. Saugy M, Avois L, Saudan C, et al. Cannabis and sport. Br J Sports Med. 2006;40(Suppl 1):i13–i15. [PMC free article] [PubMed] [Google Scholar]

60. National Collegiate Athletic Association Drug testing. 2012. [Accessed April 20, 2013]. Available from: http://www.ncaa.org/wps/wcm/connect/public/NCAA/Health+and+Safety/Drug+Testing/Drug+Testing+Landing+Page.

61. World Anti-Doping Agency 2013. [Accessed April 18, 2013]. Available from: http://www.wada-ama.org/en.

62. Morse ED. Sports psychiatrists working in college athletic departments. In: Baron DA, Reardon CL, Baron SH, editors. Clinical Sports Psychiatry: An International Perspective. Chichester, UK: Wiley; 2013. [Google Scholar]

63. Harcourt PR, Unglik H, Cook JL. A strategy to reduce illicit drug use is effective in elite Australian football. Br J Sports Med. 2012;46:943–945. [PMC free article] [PubMed] [Google Scholar]

64. Johnson MB, Sacks DN, Edmonds WA. Counseling athletes who use performance-enhancing drugs: a new conceptual framework linked to clinical practice. J Soc Behav Health Sci. 2010;4:1–29. [Google Scholar]

65. Bamberger M, Yaeger D. Over the edge. Sports Illustrated. Apr 14, 1997. [Accessed June 17, 2014]. Available from; http://sportsillustrated.cnn.com/vault/article/magazine/MAG1009868/index.htm.

66. Corcoran JP, Longo ED. Psychological treatment of anabolic-androgenic steroid-dependent individuals. J Subst Abuse Treat. 1992;9:229–235. [PubMed] [Google Scholar]

67. Goldberg L, Bents R, Bosworth E, Trevisan L, Elliot DL. Anabolic steroid education and adolescents: do scare tactics work? Pediatrics. 1991;87:283–286. [PubMed] [Google Scholar]


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Substance use rates among different populations of athletes as reported in various recent research studies

SubstanceAthlete populationPercentage of athletes using substance
Any substances banned by WADAElite athletes across sports (positive drug tests)2% over past year5
AlcoholCollege athletes (self report)75%–93% for male athletes; 71%–93% for female athletes over past year6
85% over past year7
Anabolic steroidsHigh school students (self report)0.7%–6.6% over past year8
College athletes (self report)0.2%–5% for males depending on sport; 0.0%–1.6% for females depending on sport over past year7,8
Professional football players (self report)9% used at some point in career8
Competitive power lifters (self report)67% used at some point in career8
CannabisCollege athletes (self report)28% over past year7
OpiatesProfessional football players (self report)52% used at some point in career (71% of those misused at some point in career)9
Smokeless tobaccoCollege athletes (self report)23% over past year7
College baseball players (self report)40%–50% over past year10
Professional baseball players (self report)35%–40% over past year10
Professional football players (self report)20%–30% over past year10
StimulantsCollege athletes (self report)3% over past year6