What is the polymer of nucleic proteins?

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Schematic representation of ORF1p. The top diagram shows the location of the major domains in the ORF1p of an active L1Pa1 element (the L1.3 member of the Ta-1 subfamily, respective refs 4 and 38). The amino acids corresponding to the predicted coiled-coil domain (41), the RNA recognition motif (RRM, ref. 25), and the C-terminal domain (CTD, ref. 30) are shown in Supplementary Figure S1. The arrow indicates the start of the N-terminal deletion mutant, M128p (see text and Supplementary Data). The middle diagram depicts the trimer modeled on the relative sizes of the N-terminal region, coiled-coil domain, and C-terminal half of the mouse protein as revealed by atomic force microscopy (26). The areas of the ovals corresponding to the N-terminal region and C-terminal half are proportional to their masses. The bottom diagram depicts the M128p protein monomer.

Click on the image to see a larger version.