Which of the following describes children who have had first hand encounters with death they tend to?

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Grade I (Strong evidence)  RCTs or review of RCTS   IA Calculation of sample size and accurate standard definition of appropriate outcome variables   IB Accurate and standard definition of appropriate outcome variables

  IC Neither of the above

Grade II (Fairly strong evidence)  Prospective study with a comparison group (non-randomized controlled trial, good observational study or retrospective study that controls effectively for confounding variables)   IIA Calculation of sample size and accurate, standard definition of appropriate outcome variables and adjustment for the effects of important confounding variables

  IIB One or more of the above

Grade III (Weaker evidence)  Retrospective or observational studies   IIIA Comparison group, calculation of sample size, accurate and standard definition of appropriate outcome variables   IIIB Two or more of the above

  IIIC None of these

Grade IV (Weak evidence)
 Cross-sectional study, Delphi exercise, consensus of experts

  1. Cancer Guidance Subgroup of the Clinical Guidance Outcomes Group. Improving outcomes in breast cancer – the research evidence. Leeds: NHS Executive, 1996 [20]